Rajan: Study of variations in the posterior part of the circle of Willis using magnetic resonance angiography


Introduction

Circulus arteriosus/circle of Willis1 is an arterial anastomosis at the base of the brain that unites internal carotid [ICA] and vertebro-basilar systems. Anteriorly, anterior cerebral arteries [ACA] are connected by Anterior communicating artery [ACoA] and posteriorly, the posterior cerebral artery [PCA] of each side (from basilar) is joined to ipsilateral ICA by posterior communicating artery [PCoA].

In the posterior part of circle of Willis, basilar artery runs cephalad in pre-pontine cistern and terminates at the level of inter-peduncular cistern by bifurcating behind dorsum sellae into two posterior cerebral arteries [PCA]. PCA pass postero-laterally in circum-mesencephalic cistern, winds around cerebral peduncle and reaches above the tentorial surface, parallel with superior cerebellar artery and receives Posterior communicating artery [PCoA], a branch of C7 (communicating) segment of ICA.

Surgical nomenclature2, 3, 4 divides PCA into three parts (Figure 1)

  1. P1 segment from basilar bifurcation to junction with PCoA.

  2. P2 segment from this junction to the portion in peri-mesencephalic cistern.

  3. P3 segment that runs in calcarine fissure.

Clinically, this arterial ring has claimed widespread interest due to its propensity for variations relevant for neurosurgical, vascular and radiological interventional procedures especially with regard to cerebrovascular accidents.

Figure 1

Normal MRA image of Circle of Willis

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Materials and Methods

The study design is an observational descriptive study conducted by the department of Anatomy in collaboration with department of Imaging & Radio-Diagnosis at Pushpagiri Institute of Medical Sciences & Research Centre, Tiruvalla. The investigative modality for the study was magnetic resonance angiography (MRA) of the brain. Cerebral imaging was performed on a 1.5T MRI machine including axial T1, T2, and FLAIR (fluid attenuation inversion recovery) weighted sequences. Circle of Willis MRA was performed using three-dimensional (3D) time-off flight (TOF) sequence. The original MRA sequence for each patient is retrieved from an electronic database (DXMMR). The 215 subjects for the MRA study were taken up from those availing this investigation as part of their clinical workup or follow-up at the institute, on in-patient or outpatient basis. All MRAs of brain conducted in the institution on adults of both sexes in the age group between 18 and 90 years were included in the study. Those excluded were images with evidence of Neurosurgical interventions (AVM repair, shunting), known or diagnosed cases of vasculopathies such as arteritis, and known craniofacial anomalies and genetic disorders.

Results

Of the 215 images of the circle of Willis, 80 (37.21%) were incomplete whereas 135(62.79%) were morphologically complete. In the posterior circulation, only 142 images had functional completeness, of which 86 showed textbook configuration (40% of total, and 60.56% of the complete posterior circles).

Morphology of component vessels

According to the vessel size on MRA images, component vessels were grouped as normal, hypoplastic [partial foetal variant], hyperplastic, or absent [complete foetal variant]

Posterior communicating artery

PCoA was normal in 165 (76.74%) images, on both right and left sides. The commonest variant observed was hyperplasia of right PCoA in 40 cases (18.6%) and left PCoA in 34 cases (15.81%). Hypoplasia was less frequent with four arteries affected on right and six on left side (Table 1). Total absence of PCoA and tortuosity of PCoA were also noted in ten images each respectively.

Table 1

Variations observed in Posterior Communicating arteries

Type of variation

Rt. PCoA

Lt. PCoA

Total

Incidence

Absent

4 (1.86%)

6 (2.79%)

10

2.32%

Hyperplasia

40 (18.6%)

34 (15.81%)

74

17.21%

Hypoplasia

1 (0.47%)

5 (2.3%)

6

1.39%

Normal

165 (76.74%)

165 (76.74%)

330

76.74%

Tortuous

5 (2.3%)

5 (2.3%)

10

2.32%

Total

215 (100%)

215 (100%)

430

100%

P1 segment of posterior cerebral artery

Of the 215 MRA images, right P1 segment was normal in 168 images (78.14%), and the left P1 was normal in 177 cases (82.33%). The commonest variation seen in P1 segment is the hypoplastic type or partial foetal variant, which occurred in 43 cases (20%) on right side, and 37 cases (17.21%) on left side. Total absence (1.86%) of P1 segment was more frequent on right side (Table 2).

Table 2

Variations observed in P1 segment of Posterior cerebral artery

Type of variation

Right P1

Left P1

Total

Incidence

Absent, Foetal variant

4 (1.86%)

1 (0.47%)

5

1.16%

Hypoplasia, partial foetal variant

43 (20%)

37 (17.21%)

80

18.62%

Normal

168 (78.14%)

177 (82.32%)

345

80.23%

Total

215 (100%)

215 (100%)

430

100%

Basilar artery

The artery was noted to be essentially normal in all the studied images.

Figure 2

Right p1 segment - complete foetal variant

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Figure 3

Left p1 segment - partial foetal variant

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Figure 4

P1 segment - Bilateral partial foetal variant

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Figure 5

Right P1 segment - Partial foetal variant, Left PCom – absent

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Discussion

In the present study of the posterior part of the circle of Willis using MRA in 215 subjects, only 142 were functionally complete. The variation in the posterior part of the circle of Willis with the highest incidence was the partial foetal variant of P1 segment of PCA, with a higher incidence on the right side (19.07%) as compared to the left (16.74%).

Unilateral hypoplasia of PCoA was found to be similar in incidence (more on right than left) in a cadaveric study by Raghavendra et al.5 and Saha et al.6 Hypoplasia of right PCoA was observed in 0.47% MRAs, and left PCoA in 2.3% MRAs. Right P1 hypoplasia occurred in 0.93% and left P1 hypoplasia occurred in 0.47% MRAs.

Hypoplasia of right and left P1 segments (partial foetal variant) was seen to be associated with hyperplasia of corresponding PCoA [extremely significant statistically, p<0.0001].

Developmentally,7, 8, 9 in the posterior part, foetal origin of PCA occurs when the embryonic posterior cerebral artery (derived from ICA) fails to regress on the right or left sides or bilaterally. Most cases of P1 segment hypoplasia is due to the abnormal regression of the anastomosis between the primitive basilar artery and primitive PCA.

Clinically, the presence of variations in the posterior part can compromise vascular blood flow before or after transition from ICA to vertebro-basilar system can impair normal development of cerebellar hemispheres (as seen in PHACE syndrome). Moreover, variations in the posterior circulation are associated with a higher incidence of migraine and posterior cerebral infarcts with an associated increased stroke risk in patients with obstructive arterial disease.10 Hypoplasia or absence of PCoA is a risk factor for the occurrence of ipsilateral watershed infarction.

Source of Funding

None.

Conflict of Interest

The authors declare that there is no conflict of interest.

References

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A Saha B Bhagyalakshmi S Mandal M Banopadhyaya Variation of posterior communicating artery in human brain: A morphological studyGomal Journal of Medical Sciences20131114246

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DH Padget WE Dandy The circle of Willis. Its embryology and anatomyIn intracranial arterial aneurysmsComstock Publishing CompanyNew York19486790

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B Saikia A Handique P Phukan D Lynser A Sarma Circle of Willis: variant forms and their embryology using gross dissection and Magnetic Resonance AngiographyInt J Anat Res20142234453



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Article History

Received : 26-12-2020

Accepted : 10-01-2021

Available online : 12-04-2021


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Article DOI

https://doi.org/10.18231/j.ijcap.2021.003


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