Attenuation of depression by Areca catechu ethanol extract in swiss albino mice


Original Article

Author Details : Srinivas Bhat U, Mohandas Rai, Sharath Kumar Krishna, Rashmi Rao

Volume : 1, Issue : 1, Year : 2016

Article Page : 1-4


Suggest article by email

Get Permission

Abstract

Background: Mood or affective disorder is psychological manifestations, depression is now known as a complex disorder involving the whole body and the diagnosis of depression is based on a heterogeneous set of symptoms.
Objectives: To evaluate antidepressant activity of Areca catechu Ethanol Extract in Swiss Albino Mice.
Materials and Methods: Adult Swiss albino mice were selected and randomly divided in to five groups as control which received normal saline, standard which received Imopramine 10mg/kg and three test groups which received Areca catechu ethanol extract at the dose of 40, 80 and 160 mg/kg respectively. All the drugs were administered intraperitonially (0.1ml/10gm) 30 minutes hour before the experiment followed by testing with forced swim test and tail suspension test successively to note the duration of immobility with the observation as meanĀ± SD and was compared with the control by using ANOVA followed by Dunnets test. p<0.05 was considered as significant.
Conclusion: We found that, acute treatment with Areca catechu ethanol extract at the dose of 80mg/kg and at the dose of 40 and 80mg/kg has shown significant antidepressant action by forced swim test and tail suspension test respectively


How to cite : Srinivas Bhat U, Rai M, Krishna S K, Rao R, Attenuation of depression by Areca catechu ethanol extract in swiss albino mice. Indian J Clin Anat Physiol 2016;1(1):1-4


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







View Article

PDF File  


Copyright permission

Get article permission for commercial use

Downlaod

PDF File    






Article Access statistics

Viewed: 1476

PDF Downloaded: 457